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KMID : 1145120180160010010
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Asian Journal of Beauty and Cosmetology
2018 Volume.16 No. 1 p.10 ~ p.19
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Anti-inflammatory Effects and Innate Immunity Suppression by Fritillaria ussuriensis Extracts
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Seo Jin-Young
Kim Jung-Suk
Kim Kum-Lan
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Abstract
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Purpose: The present study aimed to evaluate the anti-inflammatory effects, innate immunity suppression, and cosmetic activity of Fritillaria ussuriensis (FU) extracts in lipopolysaccharide (LPS)-induced inflammatory mice models using serum, blood, and histological analyses.
Methods: FU extracts were obtained by refluxing with 80% ethanol and used to investigate the anti-inflammatory and innate immune responses. Balb/c mice were divided into four groups: a normal group in which acute inflammation was not induced, a control group in which only distilled water was administered, and test groups in which 200 mg/kg/day and 400 mg/kg/day of FU extract were orally administered. After the administration, 1 mg/kg of LPS was injected intraperitoneally in the control and test groups but not the normal group. After 90 min, effects based on cytokine and immune cell analyses and skin histopathological analysis were evaluated.
Results: Compared with the control group, the test groups showed reduced serum concentrations of inflammation markers (interferon gamma (IFNγ), tumor necrosis factor alpha (TNFα), interleukin 1 beta (IL1β), and interleukin 6 (IL6)) and immune markers (white blood cell (WBC) and monocyte markers). The test groups also showed an increased number of granulocytes (neutrophils, eosinophils, and basophils). Moreover, histological examination demonstrated that the FU extract suppressed thickening of the epidermis in the test groups.
Conclusion: The results indicate that FU extracts prevented and improved acute inflammation. Thus, FU extracts may be used as raw material for preparing new health foods, medicines, or cosmetics.
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KEYWORD
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Fritillaria ussuriensis, Immune, Anti-inflammatory, Cosmetics, Cytokine
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